Metabolism of catechol estrogens by erythrocyte catechol-O methyltransferase
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منابع مشابه
Metabolism of catechol estrogens by erythrocyte catechol-O methyltransferase.
Fishman and Tulchinsky (1) present evidence that the catechol estrogen 2hydroxyestrone suppresses serum prolactin in normal ovulatory young women. However, in 3 of the 12 subjects studied the authors were unable to suppress serum prolactin and suggested that prolactin response to 2-hydroxyestrone is subjectand not time-dependent. In a study designed to evaluate the kinetics of catechol estrogen...
متن کاملCatechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and estrogen quinones has been postulated to be a factor in mammary carcinogenesis. Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concen...
متن کاملCatechol-O-Methyltransferase in Parkinson’s Disease
The introduction of levodopa therapy for Parkinson’s disease (PD), initially by Birkmayer and colleagues in 1961 and Barbeau and colleagues in 1962, and in its ultimately successful form by Cotzias and colleagues in 1967, still represents the defining landmark in the treatment of PD (1–3). This dramatic advance was preceded by methodical basic laboratory research in the late 1950s and early 196...
متن کاملCatechol-O-methyltransferase and Parkinson's disease.
Parkinson's disease (PD) is one of the main causes of neurological disability in the elderly. Levodopa is the gold standard for treating this disease, but chronic levodopa therapy is complicated by motor fluctuation and dyskinesia. The catechol-O-methyltransferase (COMT) inhibitors represent a new class of antiparkinsonian drugs. When coadministered with levodopa/decarboxylase inhibitor, 2 COMT...
متن کاملO-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols.
The human catechol-O-methyltransferase (COMT) is a polymorphic enzyme that catalyzes the O-methylation of catechol estrogens. Recent animal studies showed that placental COMT is involved in the development of placentas and embryos, probably via the formation of 2-methoxyestradiol. In this study, we analyzed a total of 36 human term placentas to determine their cytosolic COMT activity for the O-...
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ژورنال
عنوان ژورنال: Science
سال: 1981
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.7268425